25/27
(Photo by George Chinsee/WWD/Penske Media via Getty Images)
Sophia Loren
And that's not Barrymore's only famed guardian angel. A scion of screen legends, she counts Italian acting icon Sophia Loren as her godmother.
26/27
Photo by Christopher Polk/Getty Images
Bono
The U2 frontman is godfather to Angelina Jolie and Brad Pitt's twins Knox and Vivienne.
27/27
Photo by Jamie McCarthy/WireImage
Johnny Depp
The Pirates of the Caribbean actor is godfather to Tim Burton and Helena Bonham Carter's son Billy Ray Burton.