Jennifer Love Hewitt
The brunette beauty is medium Melinda Gordon on the television show Ghost Whisperer. Her character has the ability to communicate with dead people and pass along messages to the living.
Patricia Arquette
On the television series Medium, the Oscar winner plays Allison DuBois, a housewife who uses her psychic abilities to help the district attorney's office solve violent crimes.
George Clooney
In the comedy film The Men Who Stare at Goats, the acclaimed actor plays Lyn Cassady, a retired U.S. Army Special Forces operator who claims he was part of a unit of psychic soldiers.
Simon Baker
The Aussie hottie stars in The Mentalist as Patrick Jane, a former "psychic" who outs himself as a fraud so he can join the California Bureau of Investigation and hunt for the man who murdered his wife and daughter. As a consultant with the CBI, he uses his advanced observational skills to help the team solve murders.
Alyssa Milano
On Charmed, the actress is Phoebe Halliwell, a witch who possesses the power of premonition and can see the past and look into the future.
Patrick Stewart & James McAvoy
In the X-Men movies, both actors play Professor Charles Xavier, or Professor X, a mutant whose telepathic powers allow him to control and read others' minds.
Haley Joel Osment
In the thriller The Sixth Sense, the actor plays Cole Sear, a young boy who can communicate with dead spirits.
Whoopi Goldberg
Alongside Demi Moore and Patrick Swayze in 1990's Ghost, Whoopi plays Oda Mae Brown, a con artist posing as a psychic.
Mel Gibson
In What Women Want, the actor's character, Nick Marshall, thinks he has hit the jackpot when a random accident gives him the ability to read women's minds.
James Roday
The actor portrays Shawn Spencer on the detective-comedy series Psych. As a crime consultant, his character utilizes his heightened observational skills to trick people into believing he solves cases with his psychic abilities.
Steven R. McQueen
This handsome hunk plays Jeremy Gilbert on The Vampire Diaries. After his character is resurrected by magic, he becomes a medium and gains the ability to see ghosts.
Matt Damon
In the Clint Eastwood-directed drama Hereafter, the actor plays factory worker George Lonegan, a former clairvoyant who is fed up with his ability to communicate with the dead.
Charisma Carpenter
The brunette actress is Cordelia Chase on both Buffy the Vampire Slayer and its spin-off series Angel. Her character possesses the ability to see visions, which allows her to help people in danger.
John Travolta
In Phenomenon, the actor portrays George Malley, a mechanic who acquires remarkable abilities after a flash of light hits him in the head on his birthday. His special gift allows him to move objects and even predict an earthquake.
Jane Leeves
On the sitcom Frasier, the British actress plays Daphne Moon, a physical therapist who believes she is psychic. She often has "visions" that eventually end up coming true.
Anthony Michael Hall
In the television series The Dead Zone, the actor portrays Johnny Smith, a car crash victim who wakes up from a coma with psychic powers.
Greg Grunberg
The actor plays police officer Matt Parkman on the television series Heroes. His character possesses the power of telepathy, which allows him to read and control minds.