Lori Ann Allison
Depp was married to the makeup artist from 1983 to 1985.
Sherilyn Fenn
The Twin Peaks actress dated Depp in 1986 following her split from Prince.
Ellen Barkin
After several red carpet appearances in 1994, the two split following a brief relationship.
Juliette Lewis
The What's Eating Gilbert Grape co-stars reportedly dated while filming but split afterwards.
Jennifer Grey
The Dirty Dancing actress was engaged to Depp in the '80s. She recently recounted their romantic history here.
Winona Ryder
The Edward Scissorhands co-stars became engaged in 1990 and split three years later.
Kate Moss
The fashionable couple was inseparable in the '90s but split in 1998 after a four-year relationship.
Vanessa Paradis
After 14 years together, and two children, the two split up in June 2012.
Amber Heard
The actors were married from 2015 and split over a year later after she filed for divorce in late May.
Joelle Rich
A source confirmed to E! News in September 2022 that Depp was in a relationship with the attorney, who was part of the actor's legal team in his U.K. libel lawsuit against The Sun.