Lauren Graham on Gilmore Girls
Lauren Graham and Melissa McCarthy played lovable besties, Lorelei Gilmore (Graham) and Sookie St. James (McCarthy), on the popular series Gilmore Girls from 2000 to 2007. They later reprised their roles for the Netflix revival called Gilmore Girls: A Year in the Life, which dropped in 2016.
Billy Gardell on Mike & Molly
McCarthy and Billy Gardell were just the cutest couple on this CBS comedy. The duo played the titular characters on Mike & Molly, and we were sad to see their roles come to an end when the show went off the air in 2016.
Kristen Wiig in Bridesmaids
Isn't having a goofy gal pal the best? In Bridesmaids, oddball Megan (McCarthy) becomes a close confidante for the maid of honor in the film, Annie Walker (Kristen Wiig), when she's down in the dumps.
Jason Bateman in Identity Thief
McCarthy and Jason Bateman bring new meaning to the word "frenemy" in Identity Thief. In the film, Diana (McCarthy) and Sandy Patterson (Bateman) team up to clear Sandy's name for a drug deal he never made, even though Diana started him down this path by stealing his identity in the first place.
Sandra Bullock in The Heat
Sandra Bullock teamed up with McCarthy for the hilarious buddy cop flick, The Heat, back in 2013. McCarthy played Boston detective Shannon Mullins while Bullock played FBI agent Sarah Ashburn, and together they made the ultimate dream team.
Susan Sarandon in Tammy
In Tammy, McCarthy played the titular character while Susan Sarandon played her grandmother, Pearl. The movie follows the duo on a road trip together where anything and everything goes wrong. Talk about family dysfunction!
Bill Murray in St. Vincent
Vincent MacKenna (Bill Murray) plays an alcoholic, war veteran living next door to Maggie Bronstein (McCarthy) in St. Vincent. Vincent eventually develops an unlikely friendship with Maggie's son, Oliver (Jaeden Lieberher), in this emotional film.
Miranda Hart in Spy
In Spy, CIA employee Susan Cooper (McCarthy) is forced to leave her desk duties behind and get out in the field when the daughter of an arms dealer reveals she knows the identity of the agency's best agents, and plans to kill them all. Susan teams up with her work bestie Nancy B. Artingstall (Miranda Hart) in order to stop the perilous plot.
Kristen Bell in The Boss
Imagine your difficult, former boss moving in with you. Crazy, right? Well, hilarity ensues when Michelle Darnell (McCarthy) moves in with her former assistant Claire Rawlings (Kristen Bell) in The Boss, in order to rebuild her brand and become America's newest sweetheart.
Kate McKinnon in Ghostbusters
In the 2016 gender-flipped remake of Ghostbusters, physicist Abby Yates (McCarthy) joins forces with eccentric engineer Jillian Holtzmann (Kate McKinnon) after her former partner, Erin Gilbert (Wiig), disowns her work on the paranormal.
Alec Baldwin on Saturday Night Live
We can't think of a better pair to play former White House Press Secretary Sean Spicer and Donald Trump on Saturday Night Live than McCarthy and Alec Baldwin. They're just too funny!
Molly Gordon in Life of the Party
In Life of the Party, Deanna Miles (McCarthy) decides to re-enroll in college after going through a big divorce. When she does, she ends up going to the same school as her daughter Maddie (Molly Gordon), who shows her mom the ropes. The generation gap might seem strange, but it makes this such a fun flick!
Bill Barretta in The Happytime Murders
Detective Connie Edwards (McCarthy) and her puppet partner, disgraced ex-cop turned private investigator, Phil Phillips (Bill Barretta), team up to solve a series of murders in The Happytime Murders. This movie might have soft and cuddly characters, but it is definitely not for kids!
Richard E. Grant in Can You Ever Forgive Me?
Talk about partners in crime! In Can You Ever Forgive Me?, failing writer Lee Israel (McCarthy) turns to her friend Jack Hock (Richard E. Grant) for help forging letters written by late, acclaimed writers.