Hugh Laurie & Franka Potente, House
She's blurry, but that there is Franka, who appears opposite Hugh in the House season premiere as the sister-in-law of one of House's fellow mental-institution patients. According to executive producer David Shore, the two are intrigued by each other. House premieres Sept. 21 on Fox.
Jamie Bamber & Eliza Dushku, Dollhouse
Former Battlestar Galactica guy Jamie plays a wealthy financier who hires Eliza's Echo to be his wife in the season premiere of Dollhouse, titled "Vows," premiering Sept. 25 on Fox.
Evan Rachel Wood, Stephen Moyer & Lindsey Haun, True Blood
Queen Sophie, vampire Bill and Sookie's cousin Hadley Hale take in some artificial rays on Sunday's episode of True Blood.
Shenae Grimes & AnnaLynne McCord 90210
After what happened last season, Annie probably wishes she could click her heels three times and fly home to Kansas. What are the chances Naomi will help her sometime BFF out of this hot mess?
Trevor Donovan & Tristan Wilds, 90210
Introducing...Teddy! The Days of Our Lives hunk moves into prime-time soap status as a tennis star. Matthew Perry played a similar role in the original Beverly Hills, 90210 before going on to star as Chandler in Friends, so this could mean great things for the former Abercrombie & Fitch model.
Jason Segel & Alyson Hannigan, How I Met Your Mother
Here's hoping this is a flashback.
Lindsey Shaw & Ethan Peck, 10 Things I Hate About You
Squee! In the Aug. 25 episode of 10 Things, Bianca (Meaghan Martin) wants to go to the dance, but she needs a big sister chaperone, so she convinces Patrick Verona (Ethan Peck) to ask out Kat (Lindsey Shaw). Swoon.
Ben Shenkman & Jeffrey Donovan, Burn Notice
Meet Michael Westen's new "agent"—but what's in it for him?
Jennifer Jason Leigh & Justin Kirk, Weeds
Nancy's older sister is estranged no longer—at least from Andy. Just how many fringe Botwin benefits will Jill enjoy?
Hilarie Burton & Chad Michael Murray, One Tree Hill
Lucas carries his bride, Peyton, over the threshold—of Tree Hill Hospital!—in the bloody good sixth-season finale, airing May 18.
Michael Steger, Shannen Doherty & Jessica Lowndes, 90210
This prom afterbirth afterparty is off the hook!
Leighton Meester & Chace Crawford, Gossip Girl
Blair's wish comes true when she is crowned prom queen in the May 11 season finale. But shouldn't this fairy tale end with Queen B smiling in Chuck's arms?
Elizabeth Mitchell, Lost
Um, did someone leave her Hippocratic oath in the 21st century? Despite those dreadful speculations about a major character death, Juliet looks armed and dangerous in May 13's two-part season finale. And alive.
Simon Baker, The Mentalist
When Patrick Jane suspects his nemesis, serial killer Red John, is responsible for a young girl's murder, the CBI's consulting detective reveals his own dark side—and loses that cheeky grin (aw)—in the first-season finale (May 19 on CBS).
Jamie Kennedy, David Conrad, Jennifer Love Hewitt & Camryn Manheim, Ghost Whisperer
Apparently, Jim is going to make an honest woman out of his pregnant widow by (re)marrying her in GW's fourth-season finale, "The Book of Changes," May 15 on CBS. No wonder everyone looks so bewildered.