Reese Witherspoon
The Academy Award winner is slated to portray Peggy Lee in a biopic about the late singer. Nora Ephron (Sleepless in Seattle) is set to write and direct.
Jack Black
The funnyguy is set to star in Bernie, a dark comedy about a murderous funeral home director from director Richard Linklater. Rat Pack gal Shirley MacLaine also stars.
Viggo Mortensen & Amy Adams
The two stars are confirmed to be working together in the big-screen adaptation of On the Road. Mortensen is set to play Old Bull Lee, while Adams will play Jane, his emotionally damaged wife. Kristen Stewart and Garrett Hedlund are also set to appear.
Tina Fey & Meryl Streep
The award-winning actresses are set to star together in Sony's upcoming mother-daughter comedy Mommy & Me. Stanley Tucci is directing.
Tom Hardy
The Inception hottie is set to take on the role of Mad Max in the series' fourth installment, Fury Road. He's also signed on to replace Sam Worthington in director McG's romantic comedy This Means War.
Isaiah Mustafa
Old Spice Guy is on a roll! Already scheduled to appear on Chuck and in an upcoming Tyler Perry movie, the "I'm on a horse"-spouting pitchman has confirmed that he'll be appearing in the Jennifer Aniston-Jason Bateman comedy Horrible Bosses.
Edi Gathegi
Twilight's Laurent will play Darwin, the first "biracial" mutant, in the upcoming X-Men: First Class with James McAvoy.
Daniel Craig
While James Bond is delayed due to MGM's financial woes, the current 007 is hot on the heels of a new criminal conspiracy, as he's signed on to star in Sony's The Girl With the Dragon Tattoo, directed by David Fincher. Who needs Bond girls?
Daniel Radcliffe
The actor goes from Hogwarts to How to Succeed in Business Without Really Trying, a Broadway revival of the Pulitzer Prize-winning musical about...well, exactly what it sounds like it's about. The mutlitasker is also multimedia, taking the lead as a young lawyer in the film adaptation of the best-selling thriller The Woman in Black.
Alex Rodriguez
You date enough movie stars, you start to get ideas. A-Rod will join Justin Timberlake and Mila Kunis in the star-studded comedy Friends With Benefits, with producers even tailoring his shooting schedule around the upcoming ball season. Welcome to the big leagues, son.
Zac Efron
Move over, Mary-Kate and Ashley, there's a new mogul in town. After forming his own production company, Ninjas Running Wild Productions, he's set to star in no less than four films, including an untitled workplace comedy, the time-travel flick Einstein's Theory, the master thief memoir Art of the Steal and the CIA thriller Fire. Phew.
Amanda Seyfried
The busy actress takes the lead in I'm.mortal, a sci-fi thriller in which people don't age past 25—but only the rich can afford to survive in their forever-youthful bodies.
Sacha Baron Cohen & Jude Law
No, Borat isn't back. But the man who plays him is joining the Sherlock Holmes star for Martin Scorsese's first-ever kids' flick, The Adventures of Hugo Cabret. The story follows a 12-year-old orphan named Hugo, who lives in a train station and must finish what his late father started by solving the mystery of a broken robot. Ray Winstone, Ben Kingsley and screen legend Christopher Lee are also aboard.
Andy Serkis
The actor who is famous for portraying such CG creations as Gollum in The Lord of the Rings trilogy and King Kong is going ape again, as he's been cast as the lead simian in 20th Century Fox's Planet of the Apes prequel, Rise of the Apes. Serkis will play an ape who develops sentience after scientists James Franco and Freida Pinto experiment on him while seeking a cure for Alzheimer's.
Ashley Greene
The Twilight star is taking a temporary break from Team Edward to join Miley Cyrus, Demi Moore and Hung stud Thomas Jane in LOL, a remake of the 2008 French flick about a teenager (Cyrus) dealing with her mother's divorce and a breakup of her own, among other issues.
Alexander Skarsgård
There's Blood in the water indeed. The True Blood star will join Taylor Kitsch in Battleship, helmer Peter Berg's sci-fi action adventure adaptation of the famed board game. The story purportedly adds an "alien invasion" twist, as it follows an international fleet that unites to fight an otherworldly armada on the sea. Skarsgård and Kitsch will play brothers who are rival naval officers.
Ryan Reynolds & Sandra Bullock
Fortysomething funnylady falls for younger dashing hunk. Add a dash of action and you have the next big-screen outing for The Proposal stars. Bullock and Reynolds are set to reteam for Most Wanted, an action comedy that will find the two on opposite sides of the law and on the lam.
Dwayne Johnson
The Rock is ready to roll. After plying his trade in comedies of late, like Escape to Witch Mountain, the wrestler-turned-actor is getting some wheels: He's in talks to costar with Vin Diesel in Fast & Furious 5, according to his reps. He'll apparently play a good guy in the latest sequel.
Will Smith
Big Willie to the third dimension! Smith has confirmed that he and Tommy Lee Jones plan to reunite with director Barry Sonenfeld for Men In Black 3, which will shoot in 3-D. Josh Brolin is also in talks to costar. If all goes accordingly, the sci-fi comedy sequel will hit theaters May 25, 2012.
Patrick Dempsey
There's more to McDreamy than meets the eye, as the 44-year-old Grey's Anatomy star has been tapped to play Megan Fox Rosie Huntington-Whiteley's boss in Transformers 3. Michael Bay's third installment in his blockbuster series starts shooting later this month around the U.S. before heading off to Africa, Moscow and China.
Astrid Berges-Frisbey
Hey ho, me hearties! This French actress lands the role of a lifetime opposite Johnny Depp's Capt. Jack Sparrow after being cast as a mermaid named Syrena in the highly anticipated sequel The Pirates of the Caribbean: On Stranger Tides.
Zac Efron
The High School Musical hottie is graduating to more adult roles, as he's set to play a drug runner in a remake of the Swedish thriller Snabba Cash, which loosely translates to Easy Money and is set in a criminal underworld.
Neil Patrick Harris
"Tra la la la la la." NPH gets his smurf fix as he's set to play the live-action lead in Sony's Smurfs: The Movie, directed by Scooby Doo helmer Raja Gosnell. No word if the erstwhile Doogie Howser will take on resident genius Brainy Smurf. Comic legend Jonathan Winters is aboard however to voice Papa Smurf while fellow funnyman George Lopez and stage and screen star Alan Cummings will voice Grouchy Smurf and Gutsy Smurf respectively. "Kissed a Girl" singer Katy Perry is in talks to lend her pipes to Smurfette.
Carey Mulligan
The adorable Oscar nominee has a little bit of luck and lands the part of Eliza Doolittle in the upcoming movie remake of My Fair Lady, screenwriter Emma Thompson confirms to the BBC.