Jennifer Lopez
The actress is in talks to star in Overboard, a remake the 1987 Goldie Hawn-Kurt Russell comedy. Lopez would play a spoiled millionairess who falls off a yacht, gets amnesia and lives with a working-class single dad who convinces her they're married. A role for Marc Anthony maybe?
Jamie Foxx
The Oscar winner is in negotiations to join forces with Bruce Willis in Kane & Lynch, based on the popular video game. Foxx will play the latter, a schizophrenic killer who gets out of prison with Willis' Kane to retrieve a stolen fortune.
Channing Tatum & Ryan Phillippe
These dueling dudes are the lastest actors to be shortlisted for the titular superhero in The First Avenger: Captain America. Squeezing yourself into red, white and blue spandex is a small price to pay for a Marvel franchise.
Amanda Seyfried & Orlando Bloom
It's a man's world in Albert Nobbs. The young Hollywood duo joins Jonathan Rhys Meyers and Glenn Close in the drama about a 19th-century Irish woman who poses as a man in order to find work only to fall in love and cause quite the tragic love triangle.
Jennifer Garner
Well, look who's getting all Buttered up. Mrs. Ben Affleck has joined the comedy about an adopted Midwestern girl who discovers a talent for butter carving. The girl vies for the top prize in the town's annual contest alongside an über-ambitious local woman, played by Garner.
Jason Segel
How I met your Muppet? The big screen bromancer will not only write the new as yet unnamed Muppets movie, but star as the human lead. That's the sort of rainbow connection we like to see getting made.
Justin Timberlake
The "Sexyback" singer gets back together with ex-squeeze Cameron Diaz, at least on the big screen, after landing the lead in Bad Teacher. J.T. will play a substitute instructor being wooed by Diaz's foul-mouthed, money-grubbing junior high school teacher. Should be quite a reunion.
Angelina Jolie
Angie as a modern-day Lady MacBeth? Sounds perfect. The Oscar winner is in talks to star for director Darren Aronofsky in a big-screen adaptation of Serena: A Novel. She'd play the title character, a tough-as-nails woman who moves to the mountains of North Carolina and plots the murder of her husband's illegitimate child.
Christina Applegate & Alyssa Milano
This can't end well. Funny, but not well. The thespian duo are the latest stars to join Hall Pass, the Farrelly brothers comedy following two husbands who are given permission (and one week) to engage in some Tiger-like extramarital liasions without fear of spousal repercussion. Needless to say, it's a work of fiction.
Natalie Portman
The actress's sudden penchant for pot films is enough to make us downright paranoid. On the heels of Your Highness, Portman will star in and produce Best Buds, a road trip comedy that follows a cold-footed bride on the eve of her wedding, who runs scared (yet mellow) with a group of gal-pals.
Ben Stiller
You can't stop "Blue Steel," you can only hope to contain it. Or at the very least, recapture some of its box office magic, which is exactly what Paramount hopes to do, now that it's given the really, really, ridiculously good-looking green light for Derek Z. & Co. to return for Zoolander 2. The film will be written by Evil DJ Justin Theroux, who will also direct. Jonah Hill is in talks to play the Mugatu-succeeding villain.
Ryan Reynolds & Nicolas Cage
This oughta help pay off those debts. The erstwhile action stars are joining forces in The Croods, a (ready?) 3-D CG animated action comedy. Phew. The Dreamworks flick centers on a prehistoric patriarch who, along with his family, is cast out from their cave life after an earthquake and forms an unlikely friendship with a forward-thinking nomad. The film is due out on March 12, 2012.
Mickey Rourke
Finally, another "Conan" is hitting the news. Rourke is in negotiations to play the father of Conan the Barbarian in the franchise's reboot, which will focus on the titular warrior's avenging of his dear old dad's death. Jason Momoa stars as the loincloth-clad beefcake.
Freida Pinto
What is war good for? Well, a pretty good casting decision, for one. The Slumdog Millionaire beauty joins the ranks of the Greek action epic War of the Gods, playing the oracle priestess Phaedra. So, she must have seen this one coming?
Jonah Hill
Looks like he's gonna sit this one out. The Superbad star is set to star in The Sitter, a comedy (what else?) about a suspended college student who moves back in with his mom and gets roped into babysitting his three unruly neighbor kids. Funny, we didn't know Hill had an Elisabeth Shue impression holstered.
Matt Damon
The Oscar winner is coming for Camelot, attaching himself to star as iconic assassinated presidential candidate Robert F. Kennedy in a biopic based on the best-selling biography Robert F. Kennedy: His Life.
Jude Law & Matt Damon
The talented reconnection? Oh, yeah. The megawatt former costars are reteaming, this time under the watchful eye of Steven Soderbergh and, quite possibly, alongside Kate Winslet and Marion Cotillard for the action-thriller Contagion. The film centers on the spread of a deadly disease and, like Soderbergh's Traffic, follows multiple plot lines. Here's hoping at least one requires the removal of a shirt.
Amy Adams & Patrick Dempsey
We guess being in the family way makes family movies sound all the more appealing. As does the fact that your first try grossed $340 million worldwide—which is why Disney has greenlit Enchanted 2, and is trying to reenlist the original cast. Sounds like a fairy tale ending.
Vin Diesel & Paul Walker
It's fast, it's furious, it's a franchise that can't be stopped. The dynamic auto-loving duo may be back for a fifth round of reckless driving, racing to screens in 2011. May we suggest Fastest and Furiousest?
Christian Bale, Javier Bardem & Rachel McAdams
They are not done professionally! The intriguing trio is teaming up for an as yet untitled romantic drama from director Terrence Malick. Which means this is about all the details you're gonna get for a long, long time.
Miley Cyrus & Demi Moore
You don't need to be on Twitter to LOL. The duo is set to play a lovelorn mother-daughter pair in the remake of the French hit LOL: Laughing Out Loud; Cyrus dates her ex-BF's bestie after the lout dumps her over her sexual inexperience, while Moore deals with her recent divorce. Here's hoping there's a title change in the film's future.
Mel Gibson
This is a lethal combo. The Aussie actor is reteaming with Lethal Weapon writer Shane Black for the spy thriller Cold Warrior. The pic follows Gibson as a Cold War spy who comes out of retirement to combat a Russian terrorist threat by teaming up with a younger agent.
Zac Efron
The High School hottie continues his big-screen maturity apace, signing on to star and exec produce Fire. He plays a college student chosen for a CIA special project testing the fighting prowess of ordinary civilians.
Uma Thurman
Robert Pattinson has found a new Bella. But Twi-hards need not go into hysterics just yet...Uma Thurman will be starring alongside the erstwhile vamp in Bel Ami, an adaptation of Guy de Maupassant's short story chronicling a poor journalist's ascension as Paris' top playboy. Jealous?