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The Princess Diaries (2001)
Mandy Moore nailed her breakout film role as mean girl Lana Thomas in this Disney classic, which follows the life of nerdy teen Mia Thermopolis (Anne Hathaway) after she discovers she is actually a princess of a small European country called Genovia.
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A Walk to Remember (2002)
Moore stole our hearts as the terminally ill Jamie Sullivan in this Nicholas Sparks' love story. Shane West played her love interest, Landon Carter.
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How to Deal (2003)
Channeling her inner teenage angst, Moore relates to audiences as she portrays Halley Martin, a 17-year-old who has found herself disillusioned with the idea of love.
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Saved! (2004)
Christian school girl Hilary Faye (Moore) aids her friend after an unexpected pregnancy in this religious satire.
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Chasing Liberty (2004)
Charming audiences as America's first daughter, Anna Foster, Moore plays a teen who attempts to rebel against her parents and take Europe by storm in this 2004 rom-com.
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Entourage (2005)
No name change required! Moore played herself on numerous episodes of the HBO comedy, stealing hearts and causing trouble along the way.
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American Dreamz (2006)
Southern girl Sally Kendoo (Moore) woos America in this big-screen satire about reality competitions as she tries to win the singing contest American Dreamz.
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Dedication (2007)
As Lucy Reilly, Moore portrays an illustrator who must teach her new partner the error of his misogynistic ways in this 2007 drama and romance film.
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Because I Said So (2007)
Moore stars opposite Diane Keaton as Milly Wilder in this mother-daughter comedy about finding love in all the wrong places.
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License to Wed (2007)
Newly engaged Sadie Jones (Moore) battles her premarital jitters while taking a class with her husband-to-be Ben Murphy (John Krasinski), which is led by a kooky priest (Robin Williams) in this sweet rom-com.
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Grey's Anatomy (2010)
Patient Mary Portman (Moore) wins the affection of Chandra Wilson's Dr. Bailey after surviving the infamous Seattle Grace Mercy Hospital shooting and assisting the doc in saving another patient's life.
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Tangled (2010)
Moore earned her place in Disney history as the adventurous princess Rapunzel.
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Love, Wedding, Marriage (2011)
Divorce counselor Ava (Moore) tries to save her parents and herself from divorce in this romantic comedy.
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TRON: Uprising (2012)
Adding to her collection of independent female characters, Moore proves she is not one to be messed with as the voice of Mara on this animated adventure series.
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Red Band Society (2014)
Moore went from rom-com sweetheart and Disney princess to lifesaver with her role of Dr. Erin Grace, a chief surgeon working for Doctors Without Borders on this short-lived series.
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In the Deep (2016)
Moore makes surviving a shark attack look easy starring as Lisa in the underwater thriller In the Deep.
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This Is Us (2016)
Beginning in 2016, Moore has portrayed Rebecca Pearson on the NBC drama. This Is Us focuses on the Pearson family, which is comprised of Rebecca and her husband Jack (Milo Ventimiglia) and their triplets as they deal with life as babies, kids, teens, adults and more.