Charlize Theron
Oscar winner suits up to play Meredith Vickers, the Weyland Corporation executive who may or may not have ulterior motives as she leads the expedition to find humanity's origins across the galaxy.
Kate Beckinsale
Actress takes over for Sharon Stone in the role of an undercover agent who pretends to be the wife of Douglas Quaid (Colin Farrell) in this remake of Arnold Schwarzenegger's sci-fi classic.
Jennifer Lawrence
We can't wait for The Hunger Games! The Kentucky native steps up and plays Katniss Everdeen, who takes her sister's place in a fight to the death on live television in this flick. What a loving—and badass—babe.
Anne Hathaway
In The Dark Knight Rises, Hathaway channels the girls of Catwoman past and gives Batman and Gotham City a run for their money.
Adrianne Palicki
A modern Wonder Woman?! The Friday Night Lights star plays Diana Prince in the TV movie. But this super gal is sad and alone, living three different lives. That's probably no big deal, though, when she possesses super powers, right?
January Jones
Her hot bod and sexy lingerie are just two of the assets Emma Frost uses to fight and win in X-Men: First Class. In the '60s-set film, Jones' character also possesses telepathic and mind control abilities—talk about beauty and power!
Chloe Moretz
At the ripe age of 13, Moretz was taking out bad guys and looking good while doing it—note the awesome purple wig. As Hit Girl, the young star and other home-grown superheros fight crime in Kick-Ass and it's safe to say they kick some major booty!
Gwyneth Paltrow
Whodathunk this Oscar winner would switch from drama to sci-fi? But Paltrow's Pepper Potts character is the perfect counterbalance to Tony Stark in the Iron Man series.
Morena Baccarin
V in this case stands for vixen. What better way to kick off the hottest sci-fi babe gallery this side of the Milky Way than with the Rio de Janeiro-born actress who's the star of this '80s revival? Her exotic beauty and cool voice make her the perfect choice to lead the Visitors in their latest quest to make food out of humanity. All hail the Lizard Queen!
Zoe Saldana
If we're going by box office, this sci-fi babe takes the crown, starring in two of 2009's biggest hits. Saldana plays a young Uhura in J.J. Abrams' summer reboot of Star Trek and the Na'vi princess Neytiri in James Cameron's epic Avatar. 3-D never looked so good!
Olivia Wilde
The sci-fi movie–and beauty–we've been waiting for. The House star has fanboys at attention after landing the role of the love interest in Tron: Legacy, a reimagining of Disney's 1982 cult classic cyber-adventure.
Marion Cotillard
After wooing Johnny Depp and Daniel Day-Lewis in Public Enemies and Nine respectively, the Oscar winner is giving Leonardo DiCaprio a shot in Christopher Nolan's sci-fi mindbender Inception.
Scarlett Johansson
The curvy actress gets into fighting form for her role as Black Widow in this summer's highly anticipated Iron Man 2. Johansson goes undercover in Tony Stark's office as a S.H.I.E.L.D spy. No word what Pepper Potts thinks of that!
Moon Bloodgood
With a cool-sounding name like that, how could we forget her? The model turned actress gives Sarah Connor a run for her money playing a Resistance pilot who aids Sam Worthington's amnesiac cyborg in last year's Terminator: Salvation.
Malin Ackerman
The Swedish-born blonde dons a brunette wig for her part as latex-loving Laurie Jupiter/Silke Spectre in Zack Snyder's big screen adaptation of Watchmen, the famed graphic novel by Alan Moore and Dave Gibbons.
Alice Braga
Hot off of Repo Men, the Brazilian actress teams up with Adrien Brody, Lawrence Fishburne and Topher Grace in the forthcoming sci-fi actioner Predators. She plays a South American special forces black ops sniper. We hear she's a good shot.
Milla Jovovich
The Resident Evil actress has been a sci-fi staple going all the way back to 1997's The Fifth Element. In last year's The Fourth Kind, Milla plays an Alaska psychologist investigating alien abductions.
Alessandra Torresani
The 22-year-old thesp plays Zoe Graystone, the daughter of Eric Stoltz's character in Caprica, the long-awaited prequel spinoff to SyFy's critically-acclaimed Battlestar Galactica revival. No doubt, she's the apple of fanboys' eyes.