Freddie Highmore, The Spiderwick Chronicles
In this 2008 fantasy adventure based on the book series of the same name, the future Good Doctor star played the Grace twins, Jared and Simon.
Sarah Paulson, American Horror Story: Freak Show
Paulson's played many different characters over the course of her tenure on Ryan Murphy's anthology, sometimes even within the same installment, but in the fourth, she had the distinction of playing conjoined twins Bette and Dot Tattler.
Mireille Enos, Big Love
Before her breakout role on The Killing, Enos appeared on HBO's polygamy drama as twins JoDean and Kathy Marquart.
Jason Sudeikis, Eastbound & Down
The SNL vet appeared on the HBO comedy's third season as twins Shane and Cole Gerald.
Jackie Chan, Twin Dragons
In this 1992 Hong Kong action-comedy, the legendary martial artist starred as twins separated at birth.
Bette Midler and Lily Tomlin, Big Business
In this 1988 farce loosely based on William Shakespeare's The Comedy of Errors, the icons each starred as a set of identical twins mismatched at birth, with one of each pair growing up in a wealthy urban family and the other in a poor rural family.
Jean-Claude Van Damme, Double Impact
In this 1991 action flick, the iconic Belgian actor starred as twins Chad and Alex Wagner.
Vanessa Hudgens, The Princess Switch
The High School Musical alum starred as Lady Margaret Delacourt, Duchess of Montenaro and the identical looking baker Stacy DeNovo in Netflix's 2018 update on The Prince and the Pauper, as well as in the forthcoming sequel, The Princess Switch: Switched Again.
James Franco, The Deuce
For three seasons, the Disaster Artist actor played twins Vincent and Frankie Martino, a bartender and a gambler, respectively, who get embroiled in with the Mob in late '70s-NYC in this HBO drama from The Wire creator David Simon.
Mark Ruffalo, I Know This Much Is True
The Avengers star will play identical twins Dominick and Thomas Birdsey in this limited-series adaptation of Wally Lamb's novel of the same name from director Derek Cianfrance, premiering on HBO on May 10, 2020.
Yael Grobglas, Jane the Virgin
For much of the CW hit's five-season run, the Israeli actress played both the scheming Petra and her twin sister Anezka.
Alexandra Chando, The Lying Game
On this ABC Family series loosely based on the book series of the same name, which aired for two seasons from 2011-13, the As the World Turns alum played identical twins Emma Becker and Sutton Mercer who discover one another as teenagers after being separated at birth.
Troian Bellisario, Pretty Little Liars
In the seventh season of the Freeform hit, we learned that Bellisario's Spencer Hastings had an evil twin named Alex Drake and she began pulling double duty.
Sarah Michelle Gellar, Ringer
On this short-lived 2011-12 CW series, the Buffy the Vampire Slayer legend played estranged twins Bridget Kelly and Siobhan Martin.
Lindsay Lohan, The Parent Trap
The Disney star played twins Hallie and Annie in the 1998 remake, leaving '90s kids everywhere asking, "How did they do that?!"
Ewan McGregor, Fargo
The two-time Golden Globe nominee played onscreen twins Emmit and Ray Stussy in the hit drama series.
Armie Hammer, The Social Network
The actor portrayed real-life Winklevoss brothers in the 2010 Academy Award-winning film.
Mike Meyers, Austin Powers
The iconic comedian played a total of four characters over the course of three movies; most famously he played estranged twins Austin Powers and Dr. Evil.
Lisa Kudrow, Friends
The original cast member's first onscreen twin appearance as Pheobe and Ursula Buffay took place in the 1995 episode "The One With Two Parts, Part 1."
Adam Sandler, Jack and Jill
The nine-time People's Choice Award winner played fraternal twins Jack and Jill in the 2011 holiday comedy.
Dove Cameron, Liv and Maddie
With help from body doubles Emmy Buckner and Shelby Wulfert, Cameron pulled double duty as brainy basketball star Maddie and girly teen star Liv in the Disney Channel series.
Yasmine Al Massri, Quantico
The actress played CIA and FBI agent twins Nimah and Raina Amin in ABC's hit drama series.
Leonardo DiCaprio, The Man in the Iron Mask
Eighteen years before winning the Oscar for Best Actor in a Leading Role, Leonardo played twins King Louis and Phillippe in the 1998 drama.
Jeffrey Tambor, Arrested Development
The Golden Globe-winning played George and Oscar Bluth in the Fox/Netflix sitcom.