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The Goldbergs (Wednesday, September 25 on ABC)
Time for a little vacation, and a little Vacation homage. The premiere, appropriately titled "Vacation," takes the Goldberg fam on a road trip to Disneyland that obviously doesn't go as planned. And all the while, Erica's freaking out over Geoff saying "we need to talk" without telling her what they need to talk about, which is understandably stressful!
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The Good Doctor (Monday, Sept. 23 on ABC)
Romance is in the air for Shaun (Freddie Highmore) and Carly (Jasika Nicole), and it's clearly more than just what Shaun thinks was a "disastrous" first date. He spends the premiere, titled "Disaster," desperately trying to save a newlywed woman's life while the residents compete to lead surgeries.
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The Good Place (Thursday, Sept. 26 on NBC)
All good things must come to an end, and what an end we're in for. D'Arcy Carden calls it "an adventure of a season" on the way to the end, with lots of romance, according to William Jackson Harper. Eleanor's now in charge of the Good Place experiment, Chidi's memory of their entire love story is now wiped, and the new residents are not going to be easy to turn into good people. "This is really [Eleanor] putting everything on the line and saying I gotta step up and be a leader here and make this experiment work," Kristen Bell tells us.
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Grey's Anatomy (Thursday, Sept. 26 on ABC)
Showrunner Krista Vernoff describes the changes made at the end of last season as "pretty radical," and she says the same of their effects in season 16, with Meredith, Richard, and Alex fired, and Meredith facing charges of insurance fraud. The premiere will span four weeks, but Vernoff describes this as a season of consequences that will play out long past that premiere. Oh, and be worried for every. single. couple.
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Hawaii Five-0 (Friday, Sept. 27 on CBS)
McGarrett and the team get the help of a new ally (Katrina Law) after mob bosses are targeted by an assassin. Look for the team to say goodbye to one of their own.
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How to Get Away With Murder (Thursday, September 26 on ABC)
In the final season of How to Get Away With Murder, everybody's crimes are going to have to catch up to them. There may or may not be a coffin involved, and the premiere is titled "Say Goodbye."
Check back on E! News for a sneak peek of the final season on Thursday!
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Law & Order: SVU (Thursday, Sept. 26 on NBC)
History! SVU becomes the longest-running primetime drama and returning showrunner Warren Leight said season 21 will be full of change, just like an adult turning 21. Expect changes in the squad room, some famous faces as new and returning guest stars and yes, eventually resolution to lingering plot threads.
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Legacies (Thursdays, Oct. 10 on The CW)
What's a world without hope? Or rather, what is the world of Legacies without Hope Mikaelson (Danielle Rose Russell)? She essentially erased herself in the season one finale, and now it appears Landon is enjoying a picnic with Josie! We'll find out how quickly the residents of the Salvatore School will realize someone important is missing in the premiere, appropriately titled "Never Give Up Hope."
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Madam Secretary (Sunday, Oct. 6 on CBS)
It's the final season! A time jump finds Téa Leoni's Elizabeth McCord in a new position: president. How's she doing? What crisis will she face?
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Magnum P.I. (Friday, Sept. 27 on CBS)
The premiere follows Magnum as he awaits Higgins' decision on becoming his partner or not and takes the case of missing wife who witnessed her boss' murder in the middle of bank robbery.
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Modern Family (Wednesday, Sept. 25 on ABC)
It's the beginning of the end for Modern Family. In the premiere, "New Kids on the Block," new mom Haley goes up against her own parents when it comes to how to parent her new twins, and Manny directs a dog bed commercial for Jay in the hopes of winning back the girlfriend he scared away last season. (And yes, we stole that pic above from a promo, because LOOK AT THE BABIES!)
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Mom (Thursday, Sept. 26 on CBS)
Bonnie's perfect honeymoon isn't so perfect when she can't even enjoy herself, and Christy's making questionable changes at the bar in the season premiere, which is called "Audrey Hepburn and a Jalapeno Pepper."
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NCIS (Tuesday, Sept. 24 on CBS)
Ziva's back, with a grave warning for Gibbs, leading him to question why she stayed underground for all these years. "We are kicking off season 17 with two huge episodes with lots at stake physically and emotionally for Gibbs and Ziva." NCIS showrunners Steven D. Binder and Frank Cardea told E! News.
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NCIS: Los Angeles (Sunday, Sept. 29 on CBS)
"The season 11 premiere starts immediately where the cliffhanger ended last season…," NCIS: Los Angeles showrunner R. Scott Gemmill told E! News. "Throughout the episode, circumstances will bring our team and those working with them closer and closer in proximity until ultimately they are all together. This includes a face to face reunion between Mac and Harm."
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NCIS: New Orleans( Tuesday, Sept. 24 on CBS)
"In our season premiere, Pride will suffer from insomnia and nightmares as a result of being kidnapped and drugged at the end of last season," NCIS: NOLA showrunners Christopher Silber and Jan Nash said. "The nightmares will eventually lead Pride to a long buried secret: one that lies at the heart of his desire to help others, no matter what the cost."
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New Amsterdam (Tuesday, Sept. 24 on NBC)
"We're not gonna mess around. Who died? We know we've kept you in suspense," showrunner David Schulner said. "We know you have theories. We're going to start answering your burning questions in the first few frames of the show. Buckle up 'cause it's gonna be a ride!"
Plus, expect Max's cancer to take a surprising turn, new characters and romances.
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The Resident (Tuesday, Sept. 24 on Fox)
EP Todd Harthan gave us all the goods: A giant corporation takes over Chastain, Dr. Bell is struggling, Nic and Conrad go up against new profit-loving star neurosurgeon, Dr. Cain (Morris Chestnut), Dr. Austin is juggling his families and his connection to Dr. Oakfur, former Intern Devon now gets his own intern and a love interest. Plus, expect to very quickly find out the fate of Nic's family.
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Riverdale (Wednesday, Oct. 9 on The CW)
Riverdale's premiere will be dedicated to Luke Perry and his character, Fred Andrews, as the show finally addresses Perry's death, which happened in March with three episodes of season three left to film. Shannen Doherty guest stars in the episode, and you can expect some seriously heavy emotion, for the actors and the characters.
Don't, however, expect to get all the answers about that spring break flashforward, other than the fact that Jughead is MISSING in the trailer we debuted exclusively.
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The Rookie (Sunday, Sept. 29 on ABC)
The premiere, titled "Impact," picks up in the aftermath of a plotted attack on the city and finds Officer Bradford fighting for his life. Then, after a two week flash forward, the rookies are receiving the results of their latest training exam, leaving one officer questioning what the future holds.
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SEAL Team (Wednesday, Oct. 2 on CBS)
In "Welcome to the Refuge: Part 1," Hayes leads the team on a mission in Serbia to track down an organization linked to the bombing of multiple American military outposts.
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Schooled (Wednesday, September 25 on ABC)
Barry's back in Lainey's life, and he's not going anywhere yet. "Barry and Lainey are trying to figure out where they stand. He's now studying to be a doctor, which I think shocks many people," AJ Michalka told us. "Lainey is figuring out her first year of being a teacher...and she's kind of figuring out that there might be a crush with CB so she feels a bit torn between the two. But Barry and her end up kind of picking up where they left off a little bit at the beginning of the season."
The premiere also finds Lainey back at school after the summer, struggling not to befriend her students.
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The Simpsons (Sunday, Sept. 29 on Fox)
What to expect: The history-making season 31 premiere will feature guest stars John Legend and Chrissy Teigen, in addition to Zach Woods. Other guests this year include Jim Parsons, Jason Momoa and Jane Goodall.
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Single Parents (Wednesday, September 25 on ABC)
So much for "Summer of Freedom," which is also the title of the premiere. Instead of hanging out with Angie, Will spent the summer with Tracy, leaving Angie to write the "world's longest email" to her ex. Meanwhile, Douglas ghosted Poppy on their first date!
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Superstore (Thursday, Sept. 26 on NBC)
The Cloud 9 team is doing what they can to help Mateo after he was detained by ICE, but more challenges are coming. "Cloud 9 corporate is still busily trying to crush the store's union efforts, a robot janitor sparks worries about widespread store automation, plus they're dealing with a new district manager (guest star Justina Machado)," Gabe Miller and Jonathan Green said. "Oh, and the slow death of brick and mortar in the face of online retail. Welcome to Cloud 9.0!"