Cher
There was clearly no need for Cher to "Turn Back Time" in this shimmering black bodysuit. The then 64-year-old looked ageless in the ensemble when she presented a meat-clad Lady Gaga with the award for Video of the Year.
Lady Gaga & the Glee Cast
Not only was she the most awarded musician of the night, the stars of Glee presented her with the Moonman for Best Pop Video Award. At the time, Glee was the biggest show on TV and its stars were at the top of the A-list.
Katy Perry & Nicki Minaj
The pop stars presented the award for Best Male Video, a slam-dunk for the artist who would collaborate on "Swish Swish" in 2017.
Taylor Swift
In a bold move, the pop star debuted the song "Innocent," which was seemingly written about her and Kanye West's controversial confrontation at the MTV VMAs the year prior. With lyrics like "It's alright / Your string of lights is still bright to me / You're still innocent / Who you are is not what you did," fans were convinced that her haunting performance was a sign of forgiveness.
Justin Bieber
At one of his first MTV VMAs, the teen heartthrob stole the show with his performance of "Baby" and "U Smile." Later that night, he went home with the award for Best New Artist.
Lady Gaga
It's safe to say the singer made a big impression when she won Video of the Year, along with seven other awards. Dressed in raw beef, the star's look would be called the top fashion statement of 2010 by Time.
Eminem & Rihanna
The duo joined forces to perform "Love the Way You Lie," a true surprise since the Fenty Beauty owner initially said she was unable to attend because of scheduling conflicts.
Jared Leto
The Thirty Seconds to Mars singer made quite the entrance by leading a parade of bicyclists though the red carpet.