Ashlee & Jessica Simpson
While they might now have the same sense of style, these acting, singing and designing sisters came together recently to create a juniors clothing.
John & Joan Cusack
This brother-sister act takes home the award for costarring in the most movies together. From 1984's Sixteen Candles to 2008's War, Inc., John and Joan have worked on 10 movies together.
Zooey & Emily Deschanel
The Bones star and the New Girl actress are so tight, they even used to live next door to each other in adjoining duplexes in Los Angeles!
Julianne & Derek Hough
It's been an amazing year for this gorgeous dancing duo, with Julianne hitting the big screen in Footloose and Derek starring in his eighth season of Dancing With the Stars.
Maggie & Jake Gyllenhaal
This pair are the first and only brother-sister duo to be nominated for Academy Awards in the 21st century! Those Gyllenhaals are a loving and talented bunch!
Andrew, Luke & Owen Wilson
Who's funnier and who's cuter? It's a toss-up between these adorable funnyguys, but frankly, there's no way to go wrong with this trio!
Shirley MacLaine & Warren Beatty
They get together so rarely that who even knew these two screen legends were siblings? But like a good sister, Shirley came out to support her brother when he was honored with the American Film Institute's Lifetime Achievement Award in 2008.
Ben & Casey Affleck
These brothers are Hollywood superstars, with both bros having earned Oscars! Acting talent clearly runs in the family.