Katie Holmes, The Kennedys
The Dawson's Creek star played Jackie to Greg Kinnear's JFK in this 2011 miniseries.
Jeanne Tripplehorn, Grey Gardens
The 2009 HBO movie focuses on Jacqueline Kennedy Onassis and her eccentric realtives, Little Edie (Drew Barrymore) and Big Edie (Jessica Lange).
Laura Linney, John Adams
A revolution, a smallpox epidemic and alcoholic offspring were just some of the challenges the Golden-Globe winning actress' Abigail Adams faced in the 2008 miniseries.
Maya Rudolph, Saturday Night Live
The funnylady regularly took on Michelle Obama for the late-night sketch show.
Elizabeth Banks, W
Before sporting pink wigs as Effie Trinket, the actress played former librarian Laura Bush to Josh Brolin's George W. in the 2008 flick.
Minka Kelly, The Butler
In this upcoming flick about the White House's hired help, the Friday Night Lights actress plays Jackie Kennedy while James Marsden takes on John F. Kennedy.
Emma Thompson, Primary Colors
The Oscar-winner plays fictional FLOTUS Susan Stanton in this 1998 comedy about a POTUS (John Travolta) caught in a sex scandal.
Sigourney Weaver, Dave
When her husband, fictional President Bill Mitchell (Kevin Kline) falls into a coma, the White House staffers try to pass off an ordinary citizen (Kevin Kline)—who once caught a fish this big—as the real deal in this 1993 comedy.
Mary McDonnell, Independence Day
After an alien invasion leaves fictional first lady Marilyn Whitmore with fatal injuries, her hubby President Whitmore is more than a little hungry for revenge in the 1996 blockbuster. Good thing he's got Will Smith and Jeff Goldblum there for backup.
Jaclyn Smith, The Jacqueline Bouvier Kennedy Story
The Charlie's Angels star takes on Jackie's early years in the 1981 TV movie.
Joan Allen, Nixon
The actress' portrayal of Pat Nixon in this 1995 film earned her an Academy Award nomination.