David Boreanaz
After brooding over Buffy for three seasons as the vamp-with-a-soul Angel, Boreanaz landed his own spinoff series, Angel, which ran for five seasons. The hunky star currently is in another one of TV's most popular relationships with Emily Deschanel on Fox's Bones.
Connie Britton
Not only does she have the most perfect hair on TV, Britton also has three recent hits on her hands, thanks to her work as Tami Taylor (aka one of TV's best female characters ever) on Friday Night Lights, Vivien Harmon on the first season of FX's anthology series American Horror Story, and her current gig as country superstar Rayna Jaymes on Nashville. Britton forever, y'all!
Courteney Cox
After playing the charmingly neurotic Monica on Friends for ten years, Cox went on to join a new group of friends on Cougar Town, which debuted on ABC before moving to TBS after two seasons. Her former Friends costar and BFF Jennifer Aniston has guest starred.
Bryan Cranston
From comedic dad to one of TV's most iconic anti-heroes! Cranston became a household name as the patriarch on Malcolm in the Middle before earning several Emmys for his work as drug dealer Walter White on AMC's Breaking Bad.
Lauren Graham
Graham won us over with her witticisms as the coolest TV mom ever Lorelai Gilmore on The WB's Gilmore Girls before charming us again as Sarah Braverman on NBC's feel-good family drama Parenthood.
Matthew Fox
Fox went from leaading the Salinger siblings after the loss of their parents on Party of Five to becoming the leader of a group of castaways after their plane crashes on a mysterious island on Lost.
Alyson Hannigan
While she currently plays the quirky Lily on How I Met Your Mother, which is ending after this season, Hannigan got her start as Buffy's brainy BFF witch Willow on Buffy the Vampire Slayer.
Michael J. Fox
Fox is hoping his successful TV streak continues with his new NBC comedy The Michael J. Fox Show, which debuts this fall, after '80s sitcom Family Ties made him a household name and Spin City became a hit in 1996.
Teri Hatcher
Before becoming Wisteria Lane's lead Housewife Susan on ABC's Desperate Housewives, Hatcher starred as Superman's leading lady Lois Lane opposite Dean Cain in Lois & Clark.
Joshua Jackson
Jackson took part in one of TV's most iconic love triangles as Pacey Witter on Dawson's Creek alongside James Van Der Beek and Katie Holmes. Jackson returned to TV in the cult hit Fringe, which ended its five-year run last May. But viewers won't have to wait too long to have him back in their living rooms each week as he recently landed the lead role in Showtime's cowboy pilot The Affair.
Julianna Margulies
She exited E.R. in 2000 after earning an Emmy Award for her work as nurse Carol Hathaway and returned to TV in 2009 as Alicia Florrick on CBS' The Good Wife. Margulies has earned an Emmy and a Golden Globe for her work as the politician's wife who returns to legal practice after her husband resigns from office after a sex scandal.
Peter Krause
While he played a commitmentphobe funeral-home director on HBO's Six Feet Under, Krause currently stars a devoted father, husband, brother and son on Parenthood, opposite his real-life girlfriend Lauren Graham.
Matt LeBlanc
While the Friends alum's spinoff series Joey failed to capture viewers' interest, his Showtime series Episodes has earned LeBlanc, who plays an exaggerated version of himself, an Emmy nod.
Katey Sagal
Talk about range! Sagal first played lazy housewife Peggy Bundy opposite Ed O'Neill on Married With Children, a role which earned her four Golden Globe nominations, before taking a dramatic turn as biker gang matriarch Gemma on Sons of Anarchy. She also voices Leela on the long-running animated hit Futurama, which just recently ended its 14-year run.
Neil Patrick Harris
Before becoming the pioneer of the bro code as Barney Stinson on How I Met Your Mother, Harris became a household name after donning scrubs as a teen doctor on Doogie Howser, M.D.
Ian Somerhalder
After becoming Lost's first major casualty when his character Boone died in season one, Somerhalder went on to smolder as one of current TV's most iconic vampires, the sarcastic and sexy Damon Salvatore on The CW's hit The Vampire Diaries.
Emily VanCamp
Though she played the quintessential girls next door on The WB's beloved drama Everwood and ABC's Brothers and Sisters, VanCamp turned heads and earned praise for her work as the scorned Emily Thorne on ABC's soapy hit Revenge.