Cameron and Chase Hook Up
From a series that earned its street cred with multiple OMG moments per episode, we highlight the cream of the consistently shocking crop.
After swiping some of a drug-using patient's stash, the normally buttoned-up Cameron—who's waiting to find out if she contracted HIV from a patient who coughed blood on her—goes for it with Chase when he drops by to check on her.
Chase Screws Up for a Reason
It's House who figures out that Chase made a series of fatal decisions regarding a patient because he had just found out his estranged father had passed away.
House Wins Stacy Back
A healthy dose of deceit and, ironically, saving her husband's life got House's ex to realize she still loved him. But in the end, misery doesn't love company and House tells her to go back to her now-healthy hubby.
Foreman Is a Patient
House's right-hand doc contracts the virulent degenerative condition that already killed one patient and, though the team solves the puzzle just in time, ends up brain-damaged.
House Gets Shot
A pissed-off former patient named...wait for it...Moriarty shoots the limping doc, whom he blames for his wife's suicide, during the aftermath of which House dreams he's been getting ketamine injections that are helping his leg pain.
House Fakes Brain Cancer
While the team treats a brain-damaged pianist played by Dave Matthews, Cameron finds out House is in touch with a neurologist at another hospital. But Cuddy finds out that House had a noncancerous growth and was using someone else's medical files to be eligible for an experimental treatment.
House's Team Disbands
Chase gets fired and Foreman and Cameron decide to leave their defiant leader
House Loses His Memory
The doc knows that someone, somewhere is dying following a horrific bus crash—but he can't remember who!
Amber Dies
Wilson decides he doesn't want to know House anymore after his girlfriend dies in a bus crash she wouldn't have been in if a drunken House hadn't called needing to be picked up from a bar. And he had been trying to reach Wilson. Everybody's guilt-ridden!
Thirteen Has Huntington's Disease
Stunning people get horrible news, too. After finding out she has the deadly genetic disease in her family, House reads her test results and breaks the news himself. Foreman later risks his career when he finds out his girlfriend is actually getting the placebo in a Huntington's drug trial.
Kutner Kills Himself
Seemingly perfectly happy team member Lawrence Kutner shoots himself, sending Thirteen into an emotional tailspin and House on a search for out-of-reach answers.
House Sees Amber
Visions of Wilson's dead girlfriend keep plaguing House to the point that he gives himself an insulin shock and lands in a coma. Alas, he wakes up and she's still there. Blame the Vicodin.
House Only Thinks He Had Sex With Cuddy
The increasingly delusional doc imagines an entire affair with his boss. But not only did he not sleep with her, he actually horribly insulted her. The realization that he's lost it prompts House to check into a mental institution.
Chase Kills a Patient
The onetime seminary student purposely treats an African dictator for the wrong disease, knowing there will be deadly consequences. The guilt (or is it the pressure of suppressing his glee?) eventually tears him and Cameron apart.
Wilson Reconnects With the First Mrs. Wilson
House immediately goes into sabotage mode when Wilson starts dating his first ex-wife—Libby from Lost!
Cuddy Admits She Loves House
After mending his physical wounds after a deadly crane accident, Cuddy starts in on House's emotional wounds by telling him she loves him unconditionally. Yup, everybody lies.
High on Life
House does show up at Cuddy's bedside when she's waiting to find out if she has cancer, but things don't turn out well when she finds out he had to take drugs to be able to handle it.
House Marries a Hooker
But she's a hooker with a heart of gold! House swaps vows with call girl Dominika to help her get a green card—and to annoy Cuddy, of course.
House Cuts Out His Own Tumors
After filching experimental meds from an ongoing trial to ease his leg pain, House operates on himself in his own bathtub after the lab rats start dying.
House Smashes Into Cuddy's Place
Nothing says "I feel hurt and betrayed but would like to move on" better than ramming your car through your ex-girlfriend's living room. House may end the season walking on the beach, feeling justified, but he starts the next one in prison.
Meet Sophia and Sophie
Upon his return from prison, House gleefully finds out that Taub got his ex-wife and another woman pregnant and is now the father of two baby girls with almost the same name.
Chase Gets Stabbed
A combination of disobedience and stubbornness puts the Aussie in danger when he administers a test to a patient, knowing full well it could cause a psychotic break. Well, it does.
Wilson's a Dad—Not!
To soothe his pal's regrets about not being a dad, House reveals that an old flame of Wilson's claimed to be pregnant 11 years ago. He then later reveals that the 11-year-old kid claiming to be Wilson's son is actually an actor. Relieved, aren't you, Wilson?!
Chemo at House's House
Wilson decides he wants to kick cancer in one fell swoop—or at least die trying in the comfort of his best friend's apartment.